Potential Applications of Quantum Dots in Mapping Sentinel Lymph Node and Detection of Micrometastases in Breast Carcinoma.
- Author:
Feroz ALAM
1
;
Neha YADAV
Author Information
- Publication Type:Review
- Keywords: Breast neoplasms; Early detection of cancer; Neoplasm micrometastasis; Quantum dots; Sentinel lymph node
- MeSH: Breast; Breast Neoplasms; Cell Movement; Early Detection of Cancer; Fluorescence; Humans; Lymph Nodes; Neoplasm Metastasis; Neoplasm Micrometastasis; Nitriles; Pyrethrins; Quantum Dots; Reverse Transcriptase Polymerase Chain Reaction; Sensitivity and Specificity; Track and Field
- From:Journal of Breast Cancer 2013;16(1):1-11
- CountryRepublic of Korea
- Language:English
- Abstract: Breast cancer cure aims at complete elimination of malignant cells and essentially requires detection and treatment of any micrometastases. Here, we present a review of the current methods in use and the potential role of the quantum dots (QDs) in detection and visualization of sentinel lymph node and micrometastases in breast cancer patients. The traditional histopathological, immunohistochemical, and reverse transcriptase polymerase chain reaction procedures being used for micrometastases detection had serious drawbacks of high false negativity, specificity variations and false positivity of the results. Photon emission fluorescence multiplexing characteristics of the quantum dots make them potentially ideal probes for studying the dynamics of cellular processes over time such as continuous tracking of cell migration, differentiation, and metastases. In breast cancer, QDs based molecular and genomic detections had an unparallel high sensitivity and specificity.
