The expression of heparanase and vascular endothelial growth factor-C in human lung cancer.
- Author:
Hui TIAN
1
;
Xian-xi LIU
;
Shan-zheng WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Female; Glucuronidase; metabolism; Humans; Immunohistochemistry; Lung Neoplasms; metabolism; pathology; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Staging; Vascular Endothelial Growth Factor C; metabolism
- From: Chinese Journal of Surgery 2004;42(16):976-979
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate relationship between the expression of heparanase (HPSE) and vascular endothelial growth factor-C (VEGF-C) and tumorigenesis, progression in human lung cancer.
METHODSThe expression of HPSE and VEGF-C protein in 65 cases of lung cancer, adjacent tissues of cancer and normal tissues was tested by immunohistochemical SABC method and analysed by clinico-pathological characteristics and prognosis of lung cancer.
RESULTSThe rate of expression of HPSE and VEGF-C protein in tumor tissues (51% and 57%) was significantly higher than that in adjacent tissues of cancer (9% and 12%) and normal tissues (5% and 6%) (chi2 = 34.6, 38.8, 26.7, 28.6; P < 0.01); It was shown that HPSE and VEGF-C protein expression did significantly not correlate with the type (chi2 = 0.39, 0.41, P > 0.05) and grade of the tumor (chi2 = 0.45, 0.04, P > 0.05); but it correlated with the clinical stage (chi2 = 26.6, 20.1; P < 0.01) and survival time of the patients (chi2 = 21.5, 22.2; P < 0.01).
CONCLUSIONSThe results suggest that there be overexpression of HPSE and VEGF-C protein in lung cancer tissues, and which perhaps participate in regulation of tumorigenesis, progression in lung cancer. The expressions of HPSE and VEGF-C protein are used as an useful marker of the biological behavior of lung cancer and as an independent prognosis factor for the patients with lung cancer.