Effecting observation of 3-dimensional conformal radiotherapy combined with chemotherapy for rectal cancer of postoperative local recurrence.
- Author:
De-Hua WU
1
;
Long-Hua CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; therapeutic use; Cisplatin; administration & dosage; Combined Modality Therapy; Female; Fluorouracil; administration & dosage; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; drug therapy; mortality; radiotherapy; therapy; Postoperative Period; Radiotherapy Dosage; Radiotherapy, Conformal; adverse effects; methods; Rectal Neoplasms; drug therapy; mortality; radiotherapy; therapy; Retrospective Studies; Survival Rate
- From: Chinese Journal of Surgery 2004;42(15):901-903
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the effects of 3-dimensional conformal radiation therapy combined with chemotherapy for rectal cancer of postoperative local recurrence.
METHODSFifty-six rectal cancer patients of postoperative local recurrence were treated with 3-dimensional conformal radiotherapy (66 approximately 68 Gy in 2 Gy daily fraction) combined with chemotherapy (5-Fu 0.75, Days 1 - 5 and Days 29 - 33; Cisplatin 40 mg, Days 1 - 3 and Days 29 - 31). Acute and late radioreactions and survival rates were observed. Kaplan-Meier method was used for survival analysis.
RESULTSThe 1, 2, 3 years local control rate was 87.5%, 66.1%, 38.2%, respectively. The 1, 2, 3 years disease-free survival and overall were 82.7%, 56.6%, 30.1% and 88.3%, 66.8%, 44.2%, respectively. The median survival was 25.3 months. Acute small enteritis were the most common but acceptable radioreactions Grade 1 approximately 2. No late radioreactions occurred.
CONCLUSIONS3-dimensional conformal radiotherapy combined with chemotherapy can be considered as an effective and feasible approach to cancer patients of postoperative local recurrence.
