Treatment of paraneoplastic pemphigus with Castleman's disease.
- Author:
Wen-han WU
1
;
Yin-mo YANG
;
Xue-jun ZHU
;
Ren-gui WANG
;
Jun-hua CHEN
;
Yan-ting HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Castleman Disease; complications; diagnosis; therapy; Combined Modality Therapy; Female; Humans; Male; Paraneoplastic Syndromes; complications; diagnosis; therapy; Pemphigus, Benign Familial; complications; diagnosis; therapy; Retrospective Studies
- From: Chinese Journal of Surgery 2004;42(14):849-852
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo discuss the clinical findings and treatment of paraneoplastic pemphigus (PNP) with Castleman's disease.
METHODSTo investigate the clinical, histopathologic and CT findings of 8 cases paraneoplastic pemphigus with Castleman's disease.
RESULTSAll of 8 patients were diagnosed PNP first and were found Castleman's tumor incidently during routine examination. All 8 cases showed severe erosion or ulcer of the oral mucosa with various skin lesions. Histopathologically, there were intraepidermal acantholytic vesicle, basal cell liquefaction, necrotic keratinocytes in the epidermis and lymphocyte infiltration in the upper dermis. CT scan appeared solitary mass in these patients. Some of them were attacked by bronchiolitis obliterans. All 8 patients were failed by use of predisone. Obvious relief of PNP and pulmonary lesion occurred after tumor was rescted.
CONCLUSIONSParaneoplastic pemphigus with Castleman's disease is a rare disease. The key step is to find and resect the tumor in abdomen. CT scan should be used to detect the tumor in patients with PNP, especially, when predisone was failed in treatment.
