Effects of ulinastatin on renal ultrastructure after ischemia-reperfusion in rats.
- Author:
Cong-cong CHEN
1
;
Yan ZHOU
;
Zi-ming LIU
;
Ju-mei SUN
;
Hui-hua WANG
;
Wei-dong WU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Glycoproteins; pharmacology; Kidney; blood supply; drug effects; ultrastructure; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury; drug therapy; pathology
- From: Chinese Journal of Surgery 2004;42(14):877-880
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of ulinastatin on renal function and ultrastructure changes after renal ischemia-reperfusion in rats.
METHODSAcute ischemic renal injury model was established (45 min of bilateral renal ischemia and reperfusion for 24 h). Thirty Male SD rats were randomly divided into 3 groups: sham operation group (control group or group C, without renal ischemia), renal ischemia-reperfusion group (ischemia-reperfusion group or group I, without ulinastatin), renal ischemia-reperfusion and ulinastatin intravenous injection group (ulinastatin group or group U). BUN level, serum creatinine values and renal ultrastructure were measured.
RESULTSSerum creatinine (167 +/- 39) micromol/L and BUN concentration (21 +/- 7) mmol/L in group I were significantly higher than those in group U: serum creatinine (116 +/- 13) micromol/L and BUN concentration (14.1 +/- 2.6) mmol/L (P < 0.05). The renal ultrastructure was greatly injured in group I, meanwhile, it was obviously ameliorated in group U.
CONCLUSIONUlinastatin greatly improved renal function and provides remarkable protection on renal ultrastructure after ischemia-reperfusion of kidney in rats.
