Expression and significance of estrogen receptor isoforms in the development of human breast carcinoma.
- Author:
Shu WANG
1
;
Shan WANG
;
Jia-qing ZHANG
;
Xin-min QIAO
;
De-qi YANG
;
Fu-zhong TONG
;
Ying-jiang YE
;
Zhi-rong CUI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Breast Neoplasms; metabolism; pathology; physiopathology; Cell Line, Tumor; Estrogen Receptor alpha; biosynthesis; genetics; physiology; Estrogen Receptor beta; biosynthesis; genetics; physiology; Female; Humans; Middle Aged; RNA, Messenger; biosynthesis; Reverse Transcriptase Polymerase Chain Reaction
- From: Chinese Journal of Surgery 2004;42(13):792-794
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the estrogen receptors (ER)alpha and ERbeta expression and their relationship with clinicopathological parameters in human breast carcinoma.
METHODSSamples were obtained from 30 breast carcinoma, reverse transcriptase polymerase chain reaction was used to measure the expression of ERalpha and ERbeta mRNA.
RESULTSERalpha mRNA level was up-regulated in breast carcinoma tissue compared with adjacent normal tissue (t = 7.399, P < 0.01) while down-regulated in ERbeta. The relative ratio of ERalpha and ERbeta was decreased in normal tissue vs. carcinoma (t = 6.385, P < 0.01), in patients with lymph node metastasis vs. those without lymph node metastasis (t = 2.602, P < 0.05), in late stage carcinoma vs. early stage (t = 3.754, P < 0.05).
CONCLUSIONERalpha and ERbeta play divergent role in the development of human breast carcinoma.
