Study on the potentiation of bone marrow mesenchymal stem cells involved in sebaceous duct formation.
- Author:
Li-jun FANG
1
;
Xiao-bing FU
;
Biao CHENG
;
Tong-zhu SUN
;
Jian-fu LI
;
Rong CAO
;
Yu-xin WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Bone Marrow Cells; cytology; Cell Differentiation; Mesenchymal Stem Cell Transplantation; Mesenchymal Stromal Cells; cytology; Sebaceous Glands; cytology; Swine; Swine, Miniature; Transplantation, Autologous
- From: Chinese Journal of Surgery 2004;42(18):1136-1138
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the feasibility of differentiation of bone marrow mesenchymal stem cells (MSCs) into skin appandence.
METHODSPorcine MSCs were isolated from porcine marrow and grown in vitro. After labeling with BrdU, MSCs were engrafted to porcine skin. At 1, 2, 4 weeks after the transplantation, immunohistochemical examinations were carried out to detect the positive staining of BrdU and cytokeratin.
RESULTSA few sebaceous duct cells, which expressed cytokeratin, were also BrdU positive, and these cells were considered may to be transplanted MSCs-derived cells.
CONCLUSIONPorcine MSCs might have the potential to differentiated into sebaceous duct cells in skin.
