A Case of Adult onset Bartter Syndrome with Nephrocalcinosis.
- Author:
Min Gyu PARK
1
;
Tae Won LIM
;
Hee Taek OH
;
Seung Un SONG
;
Dong HEO
;
Hark RIM
Author Information
- Publication Type:Case Report
- Keywords: Bartter Syndrome; Hypokalemia; Metabolic Alkalosis; Nephrocalcinosis
- MeSH: Adult*; Age of Onset; Alkalosis; Bartter Syndrome*; Blood Pressure; Epithelial Cells; Extremities; Female; Humans; Hyperaldosteronism; Hypokalemia; Loop of Henle; Nephrocalcinosis*; Potassium Chloride; Spironolactone
- From:Kosin Medical Journal 2014;29(1):75-79
- CountryRepublic of Korea
- Language:Korean
- Abstract: Bartter syndrome is a renal tubular defect in electrolyte transport characterized by hypokalemia, metabolic alkalosis, hyperreninemia, hyperaldosteronism, normal blood pressure, and other clinical symptoms. As a clinical and genetical heterogeneous disorder, this syndrome can be classified into two clinical variants, antenatal Bartter syndrome and classic Bartter syndrome according to the onset age. Nephrocalcinosis is common in antenatal Bartter syndrome, but is rare in classic Bartter syndrome. It can also be classified into five genetic subtypes by the underlying mutant gene, all of which are expressed in the tubular epithelial cells of the thick ascending limb of the loop of Henle. Patients with Bartter syndrome type 1, 2 and 4 present at a younger age than classic Bartter syndrome type 3. We have experienced a case of Bartter syndrome with nephrocalcinosis in a 42-year-old woman diagnosed by biochemical and radiologic studies. We had successful response with potassium chloride and spironolactone.
