Effects of electromagnetic pulse on bone metabolism of mice in vivo.
- Author:
Kang-Chu LI
1
;
Shi-Rong MA
;
Gui-Rong DING
;
Yao GUO
;
Guo-Zhen GUO
Author Information
- Publication Type:Journal Article
- MeSH: Alkaline Phosphatase; Animals; Bone and Bones; metabolism; Electromagnetic Fields; Male; Mice; Mice, Inbred BALB C; Osteocalcin; blood
- From: Biomedical and Environmental Sciences 2009;22(6):518-521
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo study the effects of electromagnetic pulse (EMP) on bone metabolism of mice in vivo.
METHODSTwenty-four male BALB/c mice were divided into a control group and 2 experimental groups (n=8). The whole-body of mice in experimental groups were exposed to 50 kV/m and 400kV/m EMP, 400 pulses daily for 7 consecutive days at 2 seconds intervals. Alkaline phosphotase (ALP) activity, serum calcium concentration and osteocalcin level and trabecular bone volume (BV/TV, %) were measured immediately after EMP exposure by biochemical, ELISA and morphological methods.
RESULTSThe ALP activity, serum calcium concentration and osteocalcin level and BV/TV in experimental groups remained unchanged after EMP exposure. Conclusion Under our experimental conditions, EMP exposure cannot affect bone metabolism of mice in vivo.
