Protective role of salidroside against aging in a mouse model induced by D-galactose.
- Author:
Gen-Xiang MAO
1
;
Hong-Bin DENG
;
Long-Guo YUAN
;
Dian-Dong LI
;
Yi-Yang Yvonne LI
;
Zhen WANG
Author Information
- Publication Type:Journal Article
- MeSH: Aging, Premature; blood; chemically induced; prevention & control; Animals; Cerebral Cortex; metabolism; Drugs, Chinese Herbal; pharmacology; therapeutic use; Galactose; Glial Fibrillary Acidic Protein; Glucosides; pharmacology; therapeutic use; Glycation End Products, Advanced; blood; Interleukin-2; metabolism; Memory; drug effects; Mice; Mice, Inbred C57BL; Motor Activity; drug effects; Nerve Growth Factors; metabolism; Nerve Tissue Proteins; metabolism; Phenols; pharmacology; therapeutic use; Spleen; drug effects; immunology; T-Lymphocytes; drug effects
- From: Biomedical and Environmental Sciences 2010;23(2):161-166
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate the protective effects of putative AGEs (advanced glycation endproducts) inhibitor salidroside against aging in an accelerated mouse aging model induced by D-galactose.
METHODSA group of 5-month-old C57BL/6J mice were treated daily with D-galactose, D-galactose combined with salidroside, salidroside alone, and control buffer for 8 weeks. At the end of the treatment, serum AGEs levels, neurological activities, expression of glial fibrillary acidic protein (GFAP) and neurotrophin-3 (NT-3) in the cerebral cortex, as well as lymphocyte proliferation and IL-2 production were determined.
RESULTSD-galactose induced mouse aging model was developed as described before. As expected, salidroside blocked D-galactose induced increase of serum AGEs levels. It also reversed D-galactose induced aging effects in neural and immune system, as evidenced by improving motor activity, increasing memory latency time, and enhancing lymphocyte mitogenesis and interleukin-2 (IL-2) production. Furthermore, elevated expression of GFAP and NT-3 in the aged model mice was also reduced upon salidroside treatment.
CONCLUSIONSalidroside inhibits AGEs formation in vivo, which at least partially contributes to its anti-aging effect in D-galactose induced aging model.
