Effect of kangquan recipe on basic fibroblast growth factor of prostate tissue in rats.
- Author:
Yuan-peng HUANG
1
;
Jian DU
;
Zhen-feng HONG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Disease Models, Animal; Drugs, Chinese Herbal; pharmacology; Fibroblast Growth Factor 2; genetics; metabolism; Gene Expression; drug effects; Humans; Male; Prostate; drug effects; metabolism; Prostatic Hyperplasia; drug therapy; genetics; metabolism; Rats; Rats, Sprague-Dawley
- From: Chinese Journal of Integrated Traditional and Western Medicine 2008;28(8):729-732
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of Kangquan Recipe (KQR) on basic fibroblast growth factor (bFGF) in prostatic tissue of rats.
METHODSBenign prostatic hyperplasia model rat was established by injecting testosterone after castration. After being administered with KQR by gastrogavage for 30 days, the model rats were killed and their abdominal lobe prostate glands were taken for determining the protein and mRNA expressions of bFGF using immunohistochemical method and RT-polymerase chain reaction (RT-PCR) respectively.
RESULTSThe expressions of bFGF and bFGF mRNA were significantly lower in the model rats being treated with high or medium dose of KQR than those in the untreated model rats (P < 0.05 or P < 0.01), but these indexes were insignificantly different between the model rats treated with low dose of KQR and untreated model rats (P > 0.05).
CONCLUSIONKQR can effectively decrease the expression of bFGF in prostatic tissue of experimental benign prostate hyperplasia model rats.
