An Autopsy Case of Amyotrophic Lateral Sclerosis with Neuroinflammatory change.
- Author:
Seung Hyun HA
1
;
Wonki BAEK
;
Hyun Young KIM
;
Min Young NOH
;
Se Jin HWANG
;
Seung Hyun KIM
Author Information
1. Department of Neurology, Hanyang University College of Medicine, Seoul, Korea. kimsh1@hanyang.ac.kr
- Publication Type:Case Report
- Keywords:
Amyotrophic lateral sclerosis;
Autopsy;
Neuroinflammation
- MeSH:
Aged;
Amyotrophic Lateral Sclerosis;
Autopsy;
Craniocerebral Trauma;
Gliosis;
Humans;
Korea;
Motor Neurons;
Spinal Cord
- From:Journal of the Korean Neurological Association
2012;30(2):128-131
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Neuroinflammation such as reactive gliosis and microglial activations are important pathological findings of ALS. We present a first autopsy case of ALS in Korea related with neuroinflammatory change. A 67-year-old ALS patient suddenly expired due to accidental head trauma. Gross autopsy finding showed marked atrophic change in spinal cord. Pathological finding include a marked loss of motor neurons, reactive gliosis and microglial infiltrations. These findings suggest neuroinflammation may play a role in pathogenesis of ALS.
