Association between gingival crevicular fluid leptin level and periodontal parameters in patients with aggressive periodontitis

VernacularTitle:侵袭性牙周炎患者龈沟液瘦素水平与牙周临床指标的相关性分析
Author: Yunyu LIU ¹ ; Xin ZHANG ; Dong SHI ; Zhibin CHENG ; Huanxin MENG
Author Information

1. 北京大学医院口腔中心
Keywords: Aggressive periodontitis; Leptin; Attachment loss
From: Chinese Journal of Stomatology 2014;49(12):733-736
CountryChina
Language:Chinese
Abstract: Objective To determine the level of leptin in gingival crevicular fluid (GCF)of patients with aggressive periodontitis (AgP)and to analyze the relationship between leptin and periodontal cilinical parameters.Methods Fifty-four patients with AgP and 30 healthy controls were recruited.Detailed clinical examinations were conducted,and clinical parameters such as bleeding index (BI),probing depth (PD),attachment loss (AL)were recorded.Two teeth were selected as test teeth in each subject,one from posterior area and the other from anterior region.The level of GCF leptin was measured by enzyme linked immunosorbent assay.Results The level of GCF leptin in AgP patients was significantly lower than that of control subjects[(16.5±4.6) ng vs.(26.0±6.0) ng,P＜0.05].The level of GCF leptin was negatively related to BI (-0.306,P＜0.01),PD (-0.346,P＜0.01) and AL (-0.250,P＜0.01).Conclusions AgP patients have significantly decreased level of GCF leptin and the level of leptin was negatively related to BI,PD and AL.