The expression of E-cadherin, vimentin, β-catenin, transforming growth factor-β1 in oral squamous cell carcinomas
10.3760/cma.j.issn.1002-0098.2015.04.010
- VernacularTitle:口腔鳞状细胞癌中上皮-间充质转化标志物E-钙黏蛋白、波形蛋白、β-联蛋白及转化生长因子β1的表达
- Author:
Li ZHANG
1
;
Zhiyuan LU
;
Cao YIN
;
Minghan XIA
;
Siming XIE
Author Information
1. 暨南大学医学院口腔医学系
- Keywords:
Oral squamous cell carcinomas;
Vimentin;
Beta catenin;
Transforming growth factor beta1;
E-cadherin
- From:
Chinese Journal of Stomatology
2015;50(4):228-234
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of E-cadherin,vimentin,β-catenin and transforming growth factor-β 1(TGF-β 1) in oral squamous cell carcinomas(OSCC).Methods Eighty-nine cases of OSCC and 20 cases of normal oral mucosa were collected.Then the 89 cases of OSCC were classified as grade Ⅰ,Ⅱ,Ⅲ.The semiquantitative method was used to calculated the positive intensity and positive rate.The reiationship between the OSCC differentiation and the four biomarkers was analyzed.Results The median of E-cadherin was 9.00 in the normal tissue,9.00,6.00 and 6.00 in OSCC Ⅰ,Ⅱ and Ⅲ,respectively.There was significant difference between the normal group and OSCC group(Z=-4.211,P=0.000).The median of vimentin was 0.00 in the normal tissue,0.00,0.00 and 4.00 in OSCC Ⅰ,Ⅱ and Ⅲ,respectively.There was significant difference between the normal group and OSCC group(Z=-3.675,P=0.000).The median of β-catenin was 9.00 in the normal tissue,3.00,4.00 and 3.00 in OSCC Ⅰ,Ⅱ and Ⅲ,respectively.There was significant difference between the normal group and OSCC group(Z=-6.300,P=0.000).The median of TGF-β1 was 2.00 in the normal tissue,3.00,4.00 and 6.00 in OSCC Ⅰ,Ⅱ and Ⅲ,respectively.There was significant difference between the normal group and OSCC group(Z=-3.329,P=0.000).E-cadherin expression was positively correlated to β-catenin expression(r=0.327,P=-O.002),negtively correlated to vimentin expression(r=-0.386,P=0.001) and positively correlated to TGF-β1 expression(r=-0.304,P=0.004).Vimentin expression was positively correlated to TGF-β 1 expression (r=0.401,P=0.000).Conclusions E-cadherin and β-catenin in OSCC had a down-regulated expression,while the vimentin has an up-regulated expression.
