Prognostic factors of immunosuppressive therapy in children acquired aplastic anemia.
- Author:
Shu-chun WANG
1
;
Xiao-juan CHEN
;
Yao ZOU
;
Wen-yu YANG
;
Tian-feng LIU
;
Li ZHANG
;
Yu-mei CHEN
;
Ye GUO
;
Xiao-fan ZHU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Anemia, Aplastic; diagnosis; etiology; therapy; Animals; Antilymphocyte Serum; therapeutic use; Child; Child, Preschool; Cyclosporine; therapeutic use; Female; Humans; Immunosuppression; Immunosuppressive Agents; therapeutic use; Infant; Male; Prognosis; Rabbits; Retrospective Studies; Treatment Outcome
- From: Chinese Journal of Pediatrics 2009;47(8):613-616
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate prognostic factors of immunosuppressive therapy (IST) in children acquired severe aplastic anemia(SAA).
METHODSData of 56 consecutive children cases with SAA who had received rabbit anti-thymocyte globulin (R-ATG) [3-5 mg/( kg x d) x 5 d] and cyclosporine A (CSA) from January 2000 to June 2006 were retrospectively analyzed. No repeated courses of R-ATG were given for nonresponders. All the patients also received stanozolol or testosterone propionate. The dose of CSA was adjusted to maintain trough drug levels above 100 microg/L and peak drug levels above 300 microg/L.
RESULTSThe overall response rate to the immunosuppressive therapy (IST) was 62.5% and the complete remission rate was 37.5%. The 5-year overall survival for IST regimens was 66.27% +/- 6.84%, patients who had infections when using ATG had significantly lower response and higher mortality. Patients whose nucleated erythrocyte population in bone marrow was > or =10% had good prognosis. Patients whose granulocytes population in bone marrow was > or =10% had lower mortality.
CONCLUSIONPatients who had infections when using ATG had significantly lower response and higher mortality. Patients whose nucleated erythrocyte population in bone marrow was > or =10% had good prognosis.
