Successful Treatment of Relapsed Acquired Amegakaryocytic Thrombocytopenia with Repeat Cyclosporine.
10.3904/kjm.2016.90.3.258
- Author:
Soo Ya BAE
1
;
Tae Hee HAN
;
Byeong Seok SOHN
;
Hyun Ho OH
;
Seong Jin CHOI
;
Moon PARK
;
Young Jin YUH
Author Information
1. Department of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea. yjyuh@paik.ac.kr
- Publication Type:Case Report
- Keywords:
Acquired amegakaryocytic thrombocytopenia;
Cyclosporine
- MeSH:
Antilymphocyte Serum;
Bone Marrow;
Cyclosporine*;
Humans;
Megakaryocytes;
Thrombocytopenia*
- From:Korean Journal of Medicine
2016;90(3):258-261
- CountryRepublic of Korea
- Language:English
-
Abstract:
Acquired amegakaryocytic thrombocytopenia (AAMT) is an unusual disease characterized by severe thrombocytopenia resulting from a marked decrease in bone marrow megakaryocytes. Various pathogenic mechanisms have been suggested, and several treatments have been tried, with varying outcomes. In some case reports, cyclosporine and anti-thymocyte globulin have had good clinical results in the treat of AAMT. There are few reports on the treatment of relapsed AAMT with cyclosporine. We report a patient with relapsed AAMT who was treated successfully with an additional course of cyclosporine. The initial remission was achieved with cyclosporine 4 years earlier and a second remission was induced by cyclosporine. Cyclosporine may be effective for relapsed AAMT that previously responded to cyclosporine.
