Bone Marrow Microenvironment and Myelodysplastic Syndromes--Review.
10.7534/j.issn.1009-2137.2016.01.056
- Author:
Gao-Chao ZHANG
1
;
Hua-Quan WANG
1
;
Zong-Hong SHAO
2
Author Information
1. Departmeng of Hematology, General Hospital of Tianjin Medical University, Tianjin 300052.
2. Departmeng of Hematology, General Hospital of Tianjin Medical University, Tianjin 300052. E-mail: shaozonghong@sina.com.
- Publication Type:Journal Article
- MeSH:
Bone Marrow;
physiopathology;
Cellular Microenvironment;
Cytokines;
Disease Progression;
Hematopoiesis;
Humans;
Intercellular Signaling Peptides and Proteins;
Mesenchymal Stromal Cells;
Myelodysplastic Syndromes;
physiopathology
- From:
Journal of Experimental Hematology
2016;24(1):290-294
- CountryChina
- Language:Chinese
-
Abstract:
Myelodysplastic syndromes (MDS) are a group of bone marrow failure diseases. The bone marrow microenvironment consists of bone marrow stromal cells (BMSC), growth factors and cytokines. The BMSC supporting haemopoiesis include mesenchymal stem cells (MSC), osteoblasts, endothelial cells and macrophages, but the adipocytes play a role in the suppression of hematopoiesis. Recently more and more researches indicate that the abnormality of bone marrow microenvironment involves in the pathogenesis and progression of MDS. In this review the abnormality of MDS bone marrow microenvironment is summarized briefly.
