Research Advances of A New Co-stimulatory Molecule-B7 Homolog 6--Review.
10.7534/j.issn.1009-2137.2016.01.057
- Author:
Fei-Fei WU
1
;
Xiao-Yan KE
2
Author Information
1. Department of Hematology, Peking University Third Hospital, Beijing 100191, China.
2. Department of Hematology, Peking University Third Hospital, Beijing 100191, China. E-mail: xiaoyank@yahoo.com.
- Publication Type:Journal Article
- MeSH:
Autoimmune Diseases;
B7 Antigens;
metabolism;
Down-Regulation;
Humans;
Inflammation;
Killer Cells, Natural;
metabolism;
Natural Cytotoxicity Triggering Receptor 3;
metabolism;
Neoplasms
- From:
Journal of Experimental Hematology
2016;24(1):295-298
- CountryChina
- Language:Chinese
-
Abstract:
B7-H6 is a co-stimulatory molecule discoveried recently. B7-H6 is not expressed on normal cells, but specially expressed on tumor cells. It can also be expressed on antigen presenting cells (APC) by the induction. The B7-H6 expression can be downregulated by HDACi. NK cells can be activated to release TNFα and IFNγ through B7H6-NKp30 pathway. The B7-H6 molecules expressed on the cell surface can be shedded to form soluble molecules. In the meantime, the B7-H6/NKp30 pathway may be involved in the pathogenesis of primary Sjogren syndrome. B7-H6/NKp30 may become a new therapeutic target for tumor, inflammation and autoimmune diseases. This review discusses the B7-H6 and receptor sructure, the expression and significance of B7-H6, the function and regulating mechanism of B7-H6 and the soluble molecules of B7-H6.
