Recent Advances on the Immunoregulation of MicroRNA-155 in Mesenchymal Stem Cells--Review.
10.7534/j.issn.1009-2137.2016.01.058
- Author:
Xiao HAN
1
;
Lei WANG
1
;
Tao WU
1
;
Hai BAI
2
Author Information
1. Department of Hematology, Center for Hematologic Diseases of Chinese PLA, Lanzhou Military Command General Hospital, Lanzhou 730050, Gansu Province, China.
2. Department of Hematology, Center for Hematologic Diseases of Chinese PLA, Lanzhou Military Command General Hospital, Lanzhou 730050, Gansu Province, China. E-mail: baihai98@tom.com.
- Publication Type:Journal Article
- MeSH:
Cell Differentiation;
Cell Lineage;
Humans;
Mesenchymal Stromal Cells;
metabolism;
MicroRNAs;
metabolism
- From:
Journal of Experimental Hematology
2016;24(1):299-302
- CountryChina
- Language:Chinese
-
Abstract:
Mesenchymal stem cells (MSC) are capable of immunosuppression and differentiating into multiple cell lineages. MSC, which are accessed easily and less side-effects, have been a source of seed cells in tissue-engineering and cell-therapy. However, the application of MSC are limited by their differentiation of instability and easy aging. MicroRNA-155 (miR-155) is one of microRNA, which has powerful regulatory potential in a wide variety of immune cells through degrading specific mRNA after transcription and inhibiting translation of the target genes. Following the research of miR-155 deeply, it has an indispensable role in the proliferation, differentiation and immunoregulation of MSC. This review discusses the current understandings for the role of miR-155 in MSC.
