Research Progres on Relationship between the Graft-Versus-Host Disease and Cytomegalovirus Infection--Review.
10.7534/j.issn.1009-2137.2016.01.059
- Author:
Wei-Xin XIE
1
;
Wen-Fa HUANG
1
;
San-Fang TU
2
;
Yu-Hua LI
3
Author Information
1. Zhujiang Hospital, Southern Medical University, Guangzhou 510282, Guangdong Province, China.
2. Department of Hematology, Southern Medical University Zhujiang Hospital, Guangzhou 510282, Guangdong Province, China.
3. Department of Hematology, Southern Medical University Zhujiang Hospital, Guangzhou 510282, Guangdong Province, China. E-mail: Liyuhua2011gz@163.com.
- Publication Type:Journal Article
- MeSH:
Cytomegalovirus Infections;
complications;
Disease-Free Survival;
Graft vs Host Disease;
complications;
virology;
Hematopoietic Stem Cell Transplantation;
adverse effects;
Humans;
Leukemia;
therapy;
Recurrence
- From:
Journal of Experimental Hematology
2016;24(1):303-306
- CountryChina
- Language:Chinese
-
Abstract:
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) in the treatment of leukemia patients can improve overall survival and disease-free survival, and reduce relapse. Although the allo-HSCT is more widely used in the treatment of leukemia, but the graft-versus-host disease (GVHD) and cytomegalovirus (CMV) infections are the common complications, and are the major cause of mortality for patients following allo-HSCT. Previous studies showed that there might be a mutual promotive relationship between GVHD and CMV infection, but the clear relationship remained to be elucidated. The relationship of GVHD and CMV has been the focus of clinical research. Recently, a great progress has been made on researches of the relationship and its mechanism between GVHD and CMV infection. In this article, the relationship and its mechanism between GVHD and CMV infection after allo-HSCT are reviewed.
