Expression and Significance of NLRP3, ASC and AIM2 in Patients with Acute Leukemia.
- Author:
Yong-Liang ZHENG
1
;
Si-Si ZHONG
1
;
Liu-Yan XIN
1
;
Yi-Jian CHEN
2
Author Information
- Publication Type:Journal Article
- MeSH: Acute Disease; CARD Signaling Adaptor Proteins; Carrier Proteins; blood; genetics; Case-Control Studies; Cytoskeletal Proteins; blood; genetics; DNA-Binding Proteins; blood; genetics; Humans; Leukemia; blood; genetics; Leukemia, Myeloid, Acute; blood; genetics; NLR Family, Pyrin Domain-Containing 3 Protein
- From: Journal of Experimental Hematology 2016;24(2):358-362
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the expression and significance of NLR family, pyrin domain containing 3 (NLRP3), apoptosis associated speck like protein containing a CRAD (ASC) and absent in melanoma 2 (AIM2) of patients with acute leukemia.
METHODSThe petipheral blood samples of 19 patients with ALL and 41 patients with ANLL as the AL group (each 20 cases of newly diagnosed, relapsed and complete remission group) and 20 cases of non-hematologic malignancies as the control group were collected from July 2013 to July 2014 in the First Affiliated Hospital of Gannan Medical University. The expression levels of NLRP3, ASC and AIM2 in peripheral blood plasma were determined by ELISA.
RESULTSThe expression levels of NLRP3, ASC and AIM2 in plasma of control and AL complete remission groups were significantly higher than those in newly diagnosed and relapsed groups, and were with statistical significance (P < 0.05), but there were no statistical signifirance between ALL and ANLL groups (P > 0.05).
CONCLUSIONThe expression of NLRP3, ASC and AIM2 is down-regulated in the patients with acute leukemia, which maybe play a role of anti-leukemia, and provide a laboratory evidence for diagnosis and treatment of patients with acute leukemia.
