Analysis of Clinical Characteristics and Prognosis of 46 Elderly Patients with Peripheral T Cell Lymphoma (PTCL).

Teng-teng Wang; Zhi-gang Zhang; Hong-liang Yang; Qian LI; Bing Xia; Hai-feng Zhao; Yong YU; Xiao-fang Wang; Ya-fei Wang; Yi-zhuo Zhang

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Analysis of Clinical Characteristics and Prognosis of 46 Elderly Patients with Peripheral T Cell Lymphoma (PTCL).

Author: Teng-Teng WANG ¹ ; Zhi-Gang ZHANG ¹ ; Hong-Liang YANG ¹ ; Qian LI ¹ ; Bing XIA ¹ ; Hai-Feng ZHAO ¹ ; Yong YU ¹ ; Xiao-Fang WANG ¹ ; Ya-Fei WANG ¹ ; Yi-Zhuo ZHANG ²
Author Information

1. Tianjin Medical University Cancer Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Thearpy, Tianjin 300060, China.
2. Tianjin Medical University Cancer Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Thearpy, Tianjin 300060, China. E-mail: yizhuozhang111@163.com.
Publication Type:Journal Article
MeSH: Aged; Disease-Free Survival; Humans; Kaplan-Meier Estimate; Lymphoma, T-Cell, Peripheral; diagnosis; pathology; Multivariate Analysis; Prognosis; Proportional Hazards Models; Retrospective Studies; Survival Rate
From: Journal of Experimental Hematology 2016;24(2):438-443
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the clinical characteristics and prognostic factors of patients with peripheral T cell lymphoma (PTCL).
METHODSThe clinical data of 46 elderly PTCL patients admitted in Tianjin Medical University Cancer Hospital from April 2008 to August 2014 were collected, the clinical features, prognostic factors and treatments, as well as followed-up outcome were analyzed retrospectively. Survival analysis was performed by Kaplan-Meier method, and the COX proportional hazard model was used to perform multivariate analysis.
RESULTSThe median survival time was 11 months, and the expected 1-year, 2-year and 3-year overall survival rate (OS) was 50%, 36% and 33%, respectively. Univariate analysis showed that the age, ECOG score, Charlson Comorbidity Index Score, the efficacy and course of chemotherapy were all the prognostic indicators affecting the OS and progression free survival (PFS) in this cohort of elderly patients. Multivariate analysis indicated that ECOG score and course of chemotherapy were the independent prognostic indicators affecting the OS and PFS (P < 0.05).
CONCLUSIONECOG score and course of chemotherapy are of great significance for predicting the prognosis in elderly PTCL patients. The elderly patients's general condition and completion of a certain intensity of chemotherapy are an important measure to prolong survival time in elderly PTCL patients.