Synchronous second primary cancers in patients with squamous esophageal cancer: clinical features and survival outcome.
- Author:
Jin Seo LEE
1
;
Ji Yong AHN
;
Kee Don CHOI
;
Ho June SONG
;
Yong Hee KIM
;
Gin Hyug LEE
;
Hwoon Yong JUNG
;
Jin Sook RYU
;
Sung Bae KIM
;
Jong Hoon KIM
;
Seung Il PARK
;
Kyung Ja CHO
;
Jin Ho KIM
Author Information
- Publication Type:Original Article
- Keywords: Esophagus; Carcinoma, squamous cell; Neoplasms, multiple primary; Positron-emission tomography; Prognosis
- MeSH: Aged; Carcinoma, Squamous Cell/diagnostic imaging/mortality/*pathology/therapy; Esophageal Neoplasms/diagnostic imaging/mortality/*pathology/therapy; Esophagectomy; Esophagoscopy; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Staging; Neoplasms, Multiple Primary/diagnostic imaging/mortality/*pathology/therapy; Positron Emission Tomography Computed Tomography; Predictive Value of Tests; Retrospective Studies; Risk Factors; Time Factors; Treatment Outcome
- From:The Korean Journal of Internal Medicine 2016;31(2):253-259
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: Unexpected diagnosis of synchronous second primary cancers (SPC) complicates physicians' decision-making because clinical details of squamous esophageal cancer (EC) patients with SPC have been limited. We evaluated clinical features and treatment outcomes of patients with synchronous SPC detected during the initial staging of squamous EC. METHODS: We identified a total of 317 consecutive patients diagnosed with squamous EC. Relevant clinical and cancer-specific information were reviewed retrospectively. RESULTS: EC patients with synchronous SPC were identified in 21 patients (6.6%). There were significant differences in median age (70 years vs. 63 years, p = 0.01), serum albumin level (3.3 g/dL vs. 3.9 g/dL, p < 0.01) and body mass index (20.4 kg/m2 vs. 22.8 kg/m2, p = 0.01) between EC patients with and without SPC. Head and neck, lung and gastric cancers accounted for 18.2%, 22.7%, and 18.2% of SPC, respectively. Positron emission tomography-computed tomography (PET-CT) detected four cases (18.2%) of SPC that were missed on CT. Management plans were altered in 13 of 21 patients (61.9%) with detected SPC. Curative esophagectomy was attempted in 28.6% of EC patients with SPC (vs. 59.1% of patients without SPC; p = 0.006). EC patients with SPC had significantly lower 5-year survival than patients without SPC (10.6% vs. 36.7%, p = 0.008). CONCLUSIONS: Synchronous SPC were found in 6.6% of squamous EC patients, and PET-CT contributed substantially to the detection of synchronous SPC. EC patients with SPC had poor survival due to challenges of providing stage-appropriate treatment.
