Analysis of Risk Factors for Cytomegalovirus Infection after Allogeneic Hematopoietic Stem Cell Transplantation.
- Author:
Bing-Han ZOU
1
,
2
;
Qin ZHANG
1
;
Ya-Ru XU
1
;
Zhuo-Qing QIAO
1
;
Yu-Hang LI
1
;
Jian-Lin CHEN
1
;
Liang-Ding HU
1
;
Bin ZHANG
1
;
Hu CHEN
1
;
Author Information
- Publication Type:Journal Article
- MeSH: Cytomegalovirus Infections; diagnosis; epidemiology; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; adverse effects; Humans; Incidence; Kaplan-Meier Estimate; Logistic Models; Multivariate Analysis; Prednisone; administration & dosage; Retrospective Studies; Risk Factors
- From: Journal of Experimental Hematology 2016;24(2):551-555
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the incidence of cytomegalovirus infection and related risk factors after allogeneic hematopoietic cell transplantation and to develop a rational strategy for the preemptive treatment of CMV infection.
METHODSThe clinical data of 398 patients undergoing allogeneic hematopoietic cell transplantation from December 2011 to December 2014 were analyzed retrospectively by using a Kaplan Meier analysis and Logistics model.
RESULTSOut of 398 patients 233 developed post-transplant CMV infection (58.5%). Univariate analysis showed that HLA mismatch, ATG administration, acute graft versus host disease (aGVHD), using prednisone ≥ 1 mg/kg body weight or equivalent were associated with increase of CMV infection. Multivariate analysis showed that HLA mismatch (HR = 2.765, P = 0.000), ATG administration (HR = 3.866, P = 0.000), using prednisone ≥ 1 mg/kg body weight or equivalent (HR = 4.767, P = 0.000) also were associated with increase of CMV infection.
CONCLUSIONHLA mismatch, ATG administration, using prednisone ≥ 1 mg/kg are risk factors for CMV reaction.
