Autologous Peripheral Blood Hematopoietic Stem Cell Transplantation for Treating Patient with Primary Cutaneous γΔ T Cell Lymphoma.
- Author:
Zhong-Ling WEI
1
;
Lai-Quan HUANG
1
;
Yan DAI
1
;
Gui-Ping SU
1
;
Yi-Zhi JIANG
1
;
Dong-Ping HUANG
2
Author Information
- Publication Type:Journal Article
- MeSH: Asparaginase; therapeutic use; Female; Hematopoietic Stem Cell Transplantation; Herpesvirus 4, Human; isolation & purification; Humans; Immunophenotyping; Lymphoma, T-Cell, Cutaneous; therapy; Remission Induction; Transplantation, Autologous
- From: Journal of Experimental Hematology 2016;24(3):749-754
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the clinical characteristics of primary cutaneous γΔ T cell lymphoma and its treatment methods.
METHODSThe clinical data and treatment process of one woman case of primary cutaneous γ Δ T cell lymphoma diagnosed in our department were analysed. The multiple subcutaneous nodules were the main clinical features, the diagnosis of primary cutaneous γΔ T cell lymphoma was comfired by skin biopsy pathology. The immunophenotypes of lymphocytes showed CD20-, CD3+, CD4-, CD8-, CD56+, TIA-1+, Ki-67+ (about 60%); plasma cells kappa+(part)/lambda predominate+(part); histocytes CD4+, CD68/PGM1+; βF1-, epstein-barr (EB) virus showed negative EBER in situ hybridization.
RESULTSBy means of the chemotherapy regimens containing L-Asparaginase, the complete remission (CR) was achieved. Then, the patients were given autologous hematopoietic stem cell transplantation. Neutrophils were implanted after 16 days, and platelet was implanted after 18 days. Now, the patient is still in remission.
CONCLUSIONprimary cutaneous γΔ T cell lymphoma is rare and easy to be misdiagnosed. This disease is aggressive and its prognosis is poor. The large dose chemotherapy with L-asparaginase shows a certain curative efficacy, the autologous hematopoietic stem cells can prolong survival time of the patient.
