Epidemiology of chronic thromboembolic pulmonary hypertension in Korea: results from the Korean registry.
- Author:
So Young PARK
1
;
Sang Min LEE
;
Jong Wook SHIN
;
Byoung Whui CHOI
;
Hojoong KIM
;
Jae Seung LEE
;
Sang Do LEE
;
Sung Soo PARK
;
Hwa Sik MOON
;
Yong Bum PARK
Author Information
- Publication Type:Original Article ; Multicenter Study
- Keywords: Hypertension, pulmonary; Thromboembolism; Epidemiologic studies; Characteristics
- MeSH: Adult; Aged; Antihypertensive Agents/therapeutic use; Chi-Square Distribution; Chronic Disease; Drug Therapy, Combination; Endarterectomy; Female; Humans; Hypertension, Pulmonary/diagnosis/*epidemiology/mortality/therapy; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Prevalence; Prospective Studies; Pulmonary Embolism/diagnosis/*epidemiology/mortality/therapy; Registries; Republic of Korea/epidemiology; Retrospective Studies; Risk Factors; Time Factors; Treatment Outcome
- From:The Korean Journal of Internal Medicine 2016;31(2):305-312
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: The diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH) is difficult for numerous reasons and is related with a poor prognosis. In Korea, the incidence of CTEPH and its clinical features are unknown. Thus, in this study, we evaluated the clinical characteristics and outcomes of CTEPH in a Korean cohort. METHODS: This study included South Korean patients diagnosed with CTEPH between September 2008 and October 2011. Baseline characteristics, treatments and outcomes were analyzed. RESULTS: A total of 134 patients were included in this study with 76 females (56.7%). Their median age was 58.3 +/- 15.9 years and dyspnea (112 patients, 83.5%) was the most common presenting symptom. Sixty-three patients (47%) had a history of acute pulmonary embolism or deep vein thrombosis, and six (4.5%) had pulmonary tuberculosis. In total, 28 patients (21%) underwent pulmonary thromboendarterectomy (PTE), and 99 patients had medical therapy. During the study period, 18 patients (13.4%) died. In a multivariate analysis, higher hemoglobin (relative risk [RR], 1.516; 95% confidence interval [CI], 1.053 to 2.184; p = 0.025) and lower total cholesterol levels (RR, 0.982; 95% CI, 0.965 to 0.999; p = 0.037) were associated with increased mortality. CONCLUSIONS: This was the first national cohort study of Korean patients with CTEPH. Accurate diagnosis, characterization and distributions of CTEPH are imperative for prompt treatment in patients, particularly those undergoing PTE.
