Herbal extracts counteract cisplatin-mediated cell death in rat testis.
- Author:
Amr AMIN
1
;
Alaaeldin A HAMZA
;
Amr KAMBAL
;
Sayel DAOUD
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antineoplastic Agents; pharmacology; Antioxidants; pharmacology; therapeutic use; Apoptosis; drug effects; Cisplatin; pharmacology; Flowers; Ginger; Hibiscus; Magnoliopsida; Male; Oxidative Stress; drug effects; Phytotherapy; Plant Extracts; Plant Roots; Rats; Spermatozoa; drug effects; Testis; drug effects; pathology
- From: Asian Journal of Andrology 2008;10(2):291-297
- CountryChina
- Language:English
-
Abstract:
AIMTo evaluate the protective effects of ginger (Gin) and roselle (Ros) against testicular damage and oxidative stress in a cisplatin (CIS)-induced rodent model. Their protective effects against CIS-induced apoptosis in testicular and epididymal sperms is also investigated.
METHODSEthanol extracts of Gin or Ros (1 g/kg.day) were given orally to male albino rats for 26 days. This period began 21 days before a single CIS intraperitoneal injection (10 mg/kg body weight).
RESULTSGin or Ros given orally significantly restored reproductive function. Both tested extracts notably reduced the CIS-induced reproductive toxicity, as evidenced by restoring the testis normal morphology. In Gin and Ros, the attenuation of CIS-induced damage was associated with less apoptotic cell death both in the testicular tissue and in the sperms. CIS-induced alterations of testicular lipid peroxidation were markedly improved by these plant extracts.
CONCLUSIONThe present results provide further insights into the mechanisms of protection against CIS-induced reproductive toxicity and confirm the essential anti-oxidant potential of both examined extracts.