Genetic polymorphism of glutathione S-transferase T1 gene and susceptibility to idiopathic azoospermia or oligospermia in northwestern China.
- Author:
Qi-Fei WU
1
;
Jun-Ping XING
;
Kai-Fa TANG
;
Wei XUE
;
Min LIU
;
Jian-Hua SUN
;
Xin-Yang WANG
;
Xiao-Juan JIN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Azoospermia; genetics; Case-Control Studies; China; Genetic Predisposition to Disease; Glutathione Transferase; genetics; Humans; Male; Oligospermia; genetics; Polymerase Chain Reaction; Polymorphism, Genetic; Risk Factors; Sperm Motility; genetics
- From: Asian Journal of Andrology 2008;10(2):266-270
- CountryChina
- Language:English
-
Abstract:
AIMTo investigate the association of glutathione S-transferase T1 (GSTT1) gene polymorphism in patients with idiopathic azoospermia or oligospermia in the northwestern China population.
METHODSIn the case-control study, GSTT1 genotypes were identified by multiplex polymerase chain reaction (PCR) with peripheral blood DNA samples from 78 patients with idiopathic azoospermia, 103 patients with idiopathic oligospermia and 156 age-matched controls with normal sperm concentration and motility, according to the criteria adapted from World Health Organization guidelines. All of the patients and controls were from northwestern China.
RESULTSThere is a significant association between GSTT1 null genotype with idiopathic azoospermia risk (odds ratio [OR]: 2.36, 95% confidence interval [CI]: 1.33-4.20, P=0.003) or idiopathic oligospermia risk (OR: 2.00, 95% CI: 1.17-3.27, P=0.010).
CONCLUSIONGSTT1 null genotype is a predisposing risk factor for sporadic idiopathic azoospermia or oligospermia in northwestern China.
