Clinical pregnancies and livebirths achieved by intracytoplasmic injection of round headed acrosomeless spermatozoa with and without oocyte activation in familial globozoospermia: case report.
- Author:
Enver K DIRICAN
1
;
Ahmet ISIK
;
Kubilay VICDAN
;
Eran SOZEN
;
Zekiye SULUDERE
Author Information
1. Department of Embryology, Private Ankara IVF Center, Ankara 06460, Turkey. kerem@dirican.tr.tc
- Publication Type:Case Reports
- MeSH:
Acrosome;
Adult;
Female;
Humans;
Infertility, Male;
physiopathology;
therapy;
Live Birth;
Male;
Oocyte Retrieval;
Oocytes;
physiology;
Pregnancy;
Sperm Head;
ultrastructure;
Sperm Injections, Intracytoplasmic;
Spermatozoa;
abnormalities;
ultrastructure;
Treatment Outcome
- From:
Asian Journal of Andrology
2008;10(2):332-336
- CountryChina
- Language:English
-
Abstract:
We report the successful outcome of intracytoplasmic sperm injection (ICSI) treatment in two siblings with familial globozoospermia. After controlled ovarian hyperstimulation and oocyte pick-up, retrieved oocytes were mechanically activated before ICSI and a fertilization rate of 33.3% was achieved in the first case. The second couple underwent ICSI without oocyte activation and a 9.1% fertilization rate was obtained. The transfer of two grade I embryos in the first couple and one grade I embryo in the second couple resulted in clinical pregnancies with healthy livebirths. It was concluded that the main problem of cases with globozoospermia is a low fertilization rate, and even though ICSI and oocyte activation can increase this rate it is not necessarily needed to achieve a pregnancy.
