Risk Factors for the Development of Bladder Transitional Cell Carcinoma Following Surgery for Transitional Cell Carcinoma of the Upper Urinary Tract.
- Author:
Ki Ho KIM
1
;
Jae Shin PARK
;
Chun Il KIM
;
Kyung Seop LEE
Author Information
1. Department of Urology, College of Medicine, Dongguk University, Gyeongju, Korea.
- Publication Type:Original Article
- Keywords:
Transitional cell carcinoma;
Urinary tract;
Bladder neoplasm;
Recurrence
- MeSH:
Carcinoma, Transitional Cell*;
Chemotherapy, Adjuvant;
Cystoscopy;
Follow-Up Studies;
Humans;
Incidence;
Multivariate Analysis;
Recurrence;
Risk Factors*;
Urinary Bladder Neoplasms;
Urinary Bladder*;
Urinary Tract*
- From:Korean Journal of Urology
2005;46(3):229-233
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The purpose of this study was to determine the clinical and pathological risk factors for initial intravesical recurrence in patients following surgery for a transitional cell carcinoma of the upper urinary tract. MATERIALS AND METHODS: 67 patients surgically treated for a transitional cell carcinoma of the upper urinary tract, between 1994 and 2003, were reviewed. We excluded the patients with a concomitant bladder tumor or previous bladder tumor. Traditional prognostic factors, including age, gender, tumor stage, grade, location, multiplicity, structure, size, urine cytology, operation method and adjuvant chemotherapy, were analyzed with respect to disease recurrence to the bladder. RESULTS: The initial intravesical recurrence in patients following surgery for a transitional cell carcinoma of the upper urinary tract was found in 18 patients (26.9%) during a average follow-up period of 23 months (range 6 to 118). A univariate analysis of the 67 patients showed that the tumor stage and grade were significantly correlated with the incidence of a subsequent bladder tumor. On multivariate analysis, the tumor stage had a significant impact on a subsequent bladder tumor. CONCLUSIONS: The tumor stage was an important predictor of recurrence to the bladder in patients treated surgically for a transitional cell carcinoma of the upper urinary tract. For patients with a transitional cell carcinoma of the primary upper urinary tract, regular follow-up by cystoscopy and urine cytology are necessary for the detection of recurrent bladder tumors.
