Ex vivo antioxidant effects of D-004, a lipid extract from Roystonea regia fruits, on rat prostate tissue.
- Author:
Yohani PEREZ
1
;
Vivian MOLINA
;
Rosa MAS
;
Roberto MENENDEZ
;
Rosa M GONZALEZ
;
Ambar OYARZABAL
;
Sonia JIMENEZ
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Oral; Animals; Antioxidants; pharmacology; Dose-Response Relationship, Drug; Male; Malondialdehyde; metabolism; Plant Extracts; administration & dosage; pharmacology; Prostate; drug effects; metabolism; Prostatic Hyperplasia; prevention & control; Rats; Rats, Wistar
- From: Asian Journal of Andrology 2008;10(4):659-666
- CountryChina
- Language:English
-
Abstract:
AIMTo investigate whether oral treatment with D-004, a lipid extract of the Cuban royal palm fruit, produces antioxidant effects in the prostate tissue of normal and testosterone (T)-treated rats.
METHODSIn our first experiment, normal rats were distributed into five groups: one group treated with the vehicle and four groups treated with D-004 (100, 200, 400 or 800 mg/kg). In our second experiment, rats were randomized into five groups: a negative control group and four T-injected groups. The latter were comprised of a positive control group treated with the vehicle, and three groups treated with D-004 (200, 400 or 800 mg/kg).
RESULTSIn normal rats, D-004 (100-800 mg/kg) inhibited significantly and dose-dependently iron-initiated malondialdehyde (MDA) accumulation in prostate homogenates (35.7%-80.0%) vs the controls. D-004 (200-800 mg/kg) significantly reduced baseline MDA and carbonyl groups in prostate homogenates of normal rats to approximately 80% and 50%, respectively, and totally (100%) in T-treated rats.
CONCLUSIONOral treatment with D-004 reduced MDA and carbonyl groups dose-dependently and markedly in normal and T-injected rats. These findings show that D-004 given at doses effective to prevent prostate hyperplasia also produces antioxidant effects in the prostate tissue.