Meta-analysis of post-transfusion necrotizing enterocolitis in neonates.
- Author:
Hui-Kang TAO
1
;
Qin TANG
;
Ming-Yan HEI
;
Bo YU
Author Information
- Publication Type:Journal Article
- MeSH: Bias; Case-Control Studies; Enterocolitis, Necrotizing; epidemiology; etiology; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; epidemiology; etiology; therapy; Infant, Premature; Literature Based Discovery; Male; Odds Ratio; Risk Factors; Transfusion Reaction
- From: Chinese Journal of Pediatrics 2013;51(5):336-339
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo quantitatively assess the association between transfusions and the risk of necrotizing enterocolitis (NEC) in neonates.
METHODBoth Chinese and English literature published from Jan. 1985 to Nov. 2011 about the case-control study of the association between transfusions and neonatal NEC were retrieved by searching the electronic resource databases. A meta-analysis was then performed on the comparison and synthesis of findings from included studies. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using RevMan 5.0 software. Sensitivity analysis was conducted and possible publication bias was tested as well.
RESULTA total of 7 case-control studies (480 blood transfusion cases, 2845 control cases) were included. The meta-analysis with a random-effects model found a pooled OR of 3.35 (95% CI: 1.54-7.27). Sensitivity analysis showed that OR for post-transfusion NEC within 48 h was 4.21 (95% CI: 2.17-8.16). The OR was 4.29 (95% CI: 1.39-13.24) after factors such as gestational age and birth weight were de-confounded. The fail-safe number was 263.
CONCLUSIONBlood transfusion can increase the risk of NEC in neonates. The clinical application of this conclusion should be cautious due to limited reports. High-quality randomized control trials are still needed for the further proof of the association between blood transfusion and neonatal NEC.
