The Changes of Blood Glucose Control and Lipid Profiles after Short-Term Smoking Cessation in Healthy Males.
- Author:
Seong Su LEE
1
;
Jeong Seok SEO
;
Sung Rae KIM
;
Jo Eun JEONG
;
Beom Woo NAM
;
Ju Yul LEE
;
Hee Jin LEE
;
Chul LEE
;
Chang Uk LEE
;
In Ho PAIK
;
Jeong Ho CHAE
;
Sook Hee CHAI
;
Soon Jib YOO
;
Wang Youn WON
;
Dai Jin KIM
Author Information
1. Department of Endocrinology and Metabolism, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Bucheon, Korea.
- Publication Type:Original Article
- Keywords:
beta-cell function;
Insulin resistance;
Insulin sensitivity;
Lipoprotein;
Smoking cessation
- MeSH:
Blood Glucose;
Body Weight;
Cholesterol;
Cotinine;
Fasting;
Glucose;
Homeostasis;
Humans;
Insulin;
Insulin Resistance;
Lipoproteins;
Male;
Plasma;
Smoke;
Smoking;
Smoking Cessation
- From:Psychiatry Investigation
2011;8(2):149-154
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: Our aim was to evaluate the changes in blood glucose control and lipid profiles after 2-months of smoking cessation in healthy males. METHODS: Smoking abstinence was evaluated through self-report and urine cotinine levels. 12 individuals who succeeded in quitting smoking were analyzed. Fasting values of glucose and insulin were used to estimate the beta-cell activity and insulin resistance was evaluated using the Homeostasis Model Assessment (HOMA) and Quantitative Insulin Sensitivity Check Index (QUICKI). RESULTS: The data showed that the subjects had a significant increase in weight, body mass index and fasting plasma glucose levels after smoking cessation. The HOMA-Insulin Resistance and the HOMA beta-cell function increased significantly (p=0.005, p=0.047 respectively). The QUICKI showed a significant decrease (p=0.005). In addition, the low-density lipoprotein cholesterol levels decreased significantly (p=0.028); however, changes in the high-density lipoprotein cholesterol, the triglyceride and total cholesterol levels were not significant (p=0.284, p=0.445 respectively). CONCLUSION: During the initial stage of smoking abstinence, insulin resistance increased and insulin sensitivity decreased due to elevated body weight and fat composition. Therefore, it is important to educate individuals that stop smoking about the necessity of weight control during smoking cessation programs.
