Detection of periodontal pathogens in coronary atherosclerotic plaques.
- Author:
Liang-jun ZHONG
1
;
Yuan-ming ZHANG
;
Hua LIU
;
Ping LIANG
;
Abdu Rehaman MURAT
;
Shabit ASKAR
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aggregatibacter actinomycetemcomitans; isolation & purification; Coronary Artery Disease; microbiology; Female; Fusobacterium nucleatum; isolation & purification; Humans; Male; Middle Aged; Periodontitis; microbiology; Plaque, Atherosclerotic; microbiology; Polymerase Chain Reaction; Porphyromonas gingivalis; isolation & purification; Prevotella intermedia; isolation & purification
- From: Chinese Journal of Stomatology 2008;43(1):4-7
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the possible correlation between coronary heart disease and periodontitis.
METHODSSubgingival plaque samples and coronary atherosclerotic plaques were harvested from a total of 31 patients with periodontitis who scheduled for coronary artery bypass surgery. The bacteria DNA was obtained from subgingival plaque samples and coronary atherosclerotic plaques using the chelex-100 method. The extracted DNA was examined using the polymerase chain reaction (PCR) technique.
RESULTSIn coronary atherosclerotic plaques samples from the 31 patients, Porphyromonas gingivalis (Pg, 38.7%), Actinobacillus actinomycetemcomitans (Aa, 0%), Fusobacterium nucleatum (Fn, 22.6%), Prevotella intermedia (Pi, 12.9%), Bacteroides forsythus (Bf, 38.7%) were detected. The concordant presence of the same periodontal bacteria DNA in subgingival plaques and in coronary atherosclerotic plaques in the same patient was Pg 5 (16.1%), Aa 0 (0%), Pi 2 (6.5%), Fn 4 (12.9%) and Bf 8 (25.8%).
CONCLUSIONSThe presence of periodontal bacteria DNA in coronary atherosclerotic plaques could indicate that periodontal pathogenic bacteria may play a role in the coronary heart disease process.
