Effect of simvastatin on bone morphogenetic protein-2 expression in the periodontal tissue after rat tooth movement
10.3321/j.issn:1002-0098.2008.01.007
- VernacularTitle:辛伐他汀对大鼠牙移动后牙周组织中骨形成蛋白2表达的影响
- Author:
Yuan-Ping CHEN
1
;
Guang-Hong HAN
;
Chang-Wei JIN
;
Rui-Xin SHI
;
Jian-Hua HOU
Author Information
1. 吉林大学口腔医学院
- Keywords:
Simvastatin;
Orthodontics,corrective;
Tooth movement;
Bone morphogenetic protein-2
- From:
Chinese Journal of Stomatology
2008;43(1):21-25
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of systematic administration of simvastatin on the bone morphogenetie protein-2(BMP-2)expression in the periodontal tissue after rat tooth movement and on the relapse of tooth movement. Methods Orthodontic tooth movement of upper first molar was performed in 32 rats with coil spring for 21 days. The 32 rats were randomly allocated into 4 groups:negative control The simvastatin started to be administered to the experimental groups 1 day before appliances were removed,and once a day there after for 4 weeks. The negative control group received the isotonic saline only. The interdental distance between the first and second maxillary molars were measured,when appliances were removed, and 1 week and 4 weeks after tha. After the rats were sacrificed,sections of first maxillary molar and periodontal tissue were studied by immunohistochemistry. Results The number and percentage of relapse was lower in the three experimental groups than in the negative control group(P＜0.05,P＜0.01).The lower dose was given,the less relapse there was,with the lowerest dose resulting in lowest percentage of relapse(26.81% and 53.38%). BMP-2 expression in experimental groups was higher than in the negative control group,with the lowerest dose group showing the highest expression(P＜0.001). The BMP-2 expression on the tension side was slishtly stronger than that on the compression side(P＞0.05).Conclusions Systemie administration of simvastatin could decrease the extent of relapse of the orthodonticmoved tooth in rat, and the lower-dose of simvastatin seemed more effective. The possible mechanism for this may be that simvastatin functions by increasing the expression of BMP-2 in tlle periodontal tissue,accelerating the ossteoblast activity and promoting bone formation.
