Silver-ion release and particle distribution of denture base resin containing nanometer-sized silver supposed antimicrobial agent
10.3321/j.issn:1002-0098.2008.01.016
- VernacularTitle:纳米载银树脂中抗菌剂的分散及银离子析出的观察
- Author:
Ri-Yue YU
1
;
Yong-Sheng ZHOU
;
Hai-Lan FENG
;
Xi-Yun LIU
Author Information
1. 北京市世纪坛医院
- Keywords:
Silver;
Anti-bacterial agents;
Polymethacrylic acids;
Denture bases
- From:
Chinese Journal of Stomatology
2008;43(1):54-56
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution of antimicrobial agent STR-1 of nanometer level which was incorporated with ball-grinding method in the polymethylmethacrylate(PMMA)denture base,and to study the release mode of silver ions from the base. Methods The distribution of the antimierobial agent in the PMMA denture base containing STR-1 at concentrations of 0 g/L,5 g/L,and 10 g/L Was examined with scanning electronic microscopy. Then,PMMA resin bases containing STR-1 at the three concentrations were respectively immersed in artificial saliva at 37 ℃ f0r 54 days. The release of silver ions from the resin bases was surveyed with inductively coupled plasma-mass spectroscopy(ICP-MS)every 24 hours.Results The antimicrobial agent incorporated by ball-grinding method was even-distributed with individual particles of nanometer level in the PMMA resin base.The release of silver ions from the PMMA resin with antimicrobial agent was extremely slow during the test,a very small fraction of the silver ions released.At the beginning of the test,the release speed was extremely slow,the speed increased rapidly in tlle middle of the test,and at the end of the test,the speed returned to slow and steady. The cumulative release curve of silver ions was of"S" type.Conclusions STR-1 can be even-distributed in the denture base,and the silver ions release from the base with extremely slow speed.It also indicates that biological safety and long-term antimicrobial efficacy of denture base containing silver-supported antimicrobial agents of nanometer level are possibly obtained based on their slow release of silver ions.
