Optimized treatment program for unstable angina by integrative medicine based on partially observable Markov decision process.
- Author:
Yan FENG
1
;
Hao XU
;
Kai LIU
;
Xue-Zhong ZHOU
;
Ke-Ji CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Angina, Unstable; therapy; Decision Making; Decision Support Systems, Clinical; Humans; Integrative Medicine; Markov Chains
- From: Chinese Journal of Integrated Traditional and Western Medicine 2013;33(7):878-882
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo initially optimize comprehensive treatment program for treating and preventing unstable angina (UA) by integrative medicine (IM).
METHODSBased on partially observable Markov decision process model (POMDP), we chose 3 syndrome elements, i.e., qi deficiency, blood stasis, and phlegm turbidity from UA inpatients. The efficacy of treating UA by IM was objectively assessed by in-depth data mining and analyses.
RESULTSThe treatment programs for UA patients of qi deficiency syndrome, blood stasis syndrome, and phlegm turbidity syndrome were recommended as follows: nitrates +statins +clopidogrel +angiotensin II receptor blockers +heparins +Astragalus membranaceus +Condonopsis + poria and large-head atractylodes rhizome (ADR = 0.85077869); nitrates + aspirin + clopidogrel + statins + heparins + Astragalus membranaceus + safflower + peach seed + red peony root (ADR = 0.70773000); nitrates + aspirin + statins + angiotensin-converting inhibitors + snakegourd fruit + onion bulb + ternate pinellia + tangerine peel (ADR = 0.72509600).
CONCLUSIONAs a POMDP based optimized treatment programs for UA, it can be used as a reference for further standardization and formulation of UA program by integrative medicine.
