Serum Levels of Advanced Glycation End Products Are Associated with In-Stent Restenosis in Diabetic Patients.
- Author:
Eui Young CHOI
1
;
Hyuck Moon KWON
;
Chul WOO
;
Geun TAEK
;
Boyoung JOUNG
;
Bum Kee HONG
;
Young Won YOON
;
Dongsoo KIM
;
Ki Hyun BYUN
;
Tae Soo KANG
;
Se Jung YOON
;
Sung Woo KWON
;
Sung Ju LEE
;
Jong Kwan PARK
;
Hyun Seung KIM
Author Information
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords: Diabetes mellitus; coronary artery disease; angioplasty; restenosis
- MeSH: Aged; Coronary Arteriosclerosis/epidemiology/*metabolism/*therapy; Coronary Restenosis/epidemiology/*metabolism; Diabetes Mellitus, Type 2/epidemiology/*metabolism; Female; Glycosylation End Products, Advanced/*blood; Humans; Male; Middle Aged; Research Support, Non-U.S. Gov't; Risk Factors; *Stents
- From:Yonsei Medical Journal 2005;46(1):78-85
- CountryRepublic of Korea
- Language:English
- Abstract: The formation of advanced glycation end products (AGEs), in various tissues has been known to enhance immunoinflammatory reactions and local oxidant stresses in long standing diabetes. Recently, AGEs have been reported to play a role in neointimal formation in animal models of arterial injury. We attempted to determine whether the serum levels of AGEs are associated with coronary restenosis in diabetic patients. Blood samples were collected from diabetic patients with coronary artery disease undergoing stent implantation and the serum levels of AGEs were analyzed by the fluorescent intensity method. The development of in-stent restenosis (ISR) was evaluated by a 6-month follow-up coronary angiography. A total of 263 target lesions were evaluated, in 203 patients. The ISR rate in the high-AGE (> 170 U/ml) group (40.1%) was significantly higher than in the low-AGE group (< or =170 U/ml) (19.6%) (p < 0.001). Furthermore, multivariate analysis revealed that a high level of serum AGEs is an independent risk factor for the development of ISR (odds ratio, 2.659; 95% CI, 1.431-4.940; p=0.002). The serum levels of AGEs constitute an excellent predictive factor for ISR, and should be one of the guidelines for medical therapy and interventional strategy to prevent ISR in diabetic patients.
