Effect of xiaoai jiedu recipe on gene expression profiles in H22 tumor-bearing mice.
- Author:
Mian-Hua WU
1
;
Li LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cell Line, Tumor; Chemokine CCL3; metabolism; Chemokine CXCL2; metabolism; Drugs, Chinese Herbal; pharmacology; Gene Expression Profiling; Liver Neoplasms, Experimental; genetics; metabolism; Mice; Mice, Inbred ICR; Signal Transduction; drug effects
- From: Chinese Journal of Integrated Traditional and Western Medicine 2013;33(9):1232-1235
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the mechanism of Xiaoai Jiedu Recipe (XJR) for fighting against tumors by detecting tumor gene expression profiles of H22 tumor-bearing mice.
METHODSH22 tumor-bearing mice were randomly divided into the normal control group, the low dose XJR group, the medium dose XJR group, the high dose XJR group, and the Cisplatin group. The differentially expressed genes of tumor tissues in H22 tumor-bearing mice were detected by using gene chip technique. The antitumor mechanism of XJR associated signaling pathways and gene expressions were found out by pathway analysis. The chemokine signaling pathways were analyzed.
RESULTSXJP could significantly affect multiple signaling pathways associated with tumor growth, apoptosis, and immunity. XJP also could decrease expressions of CCL3 and CXCL2 in the chemokine signaling pathway.
CONCLUSIONXJP could inhibit the growth and invasion of tumor cells possibly by affecting expressions of some genes in the chemokine signaling pathway.
