Research on the relationship between chinese medical syndrome types and Th1/Th2 in bronchioloalveolar carcinoma by thoracoscopic technique.
- Author:
Jun-jie MA
1
;
Hui-ping LIU
;
Chun-xiang ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma, Bronchiolo-Alveolar; diagnosis; immunology; pathology; Adult; Aged; Female; Humans; Lung Neoplasms; diagnosis; immunology; pathology; Male; Medicine, Chinese Traditional; Middle Aged; Th1 Cells; immunology; Th1-Th2 Balance; Th2 Cells; immunology
- From: Chinese Journal of Integrated Traditional and Western Medicine 2013;33(8):1069-1071
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the relationship between Chinese medical syndrome types of bronchioloalveolar carcinoma (BAC) and Th1/Th2.
METHODSTotally 60 BAC patients were syndrome typed as qi and yin deficiency syndrome (QYDS) and qi stagnation and phlegm-blood stasis syndrome (QSPSS), 30 cases in each group. Meanwhile, 30 subjects with benign pulmonary nodules were recruited as the control group. The contents of interferon-gamma (INF-gamma), interleukin 4 (IL-4), IL-2, and IL-5 were detected using thoracoscopic technique.
RESULTSAs for Th1 (INF-gamma and IL-2), it was ranked from high to low as the control group > the QSPSS group > the QYDS group (P < 0.05). As for Th2 (IL-4 and IL-5), it was ranked from high to low as the QYDS group > the QSPSS group >the control group (P < 0.05). As for Th1/Th2 (INF-gamma/lL-4, IL-2/IL-5), it was ranked from high to low as the control group > the QSPSS group >the QYDS group (P < 0.05).
CONCLUSIONSCompared with the tissue of benign nodules, Th1 function in tumor tissue of BAC patients was weaker and Th2 function stronger. Chinese medical syndrome types of BAC had correlation with Th1/Th2. Patients of excess syndrome had stronger immunity with Th1/Th2 shifting left,while those of deficiency syndrome were predispose to humoral immunity with Thl/Th2 shifting right.
