Cyclooxygenase-2 and p53 Expression as Prognostic Indicators in Conventional Renal Cell Carcinoma.
10.3349/ymj.2005.46.1.133
- Author:
Dae Sung CHO
1
;
Hee Jae JOO
;
Dong Keun OH
;
Ji Hun KANG
;
Young Soo KIM
;
Kyi Beom LEE
;
Se Joong KIM
Author Information
1. Department of Urology, Ajou University School of Medicine, Suwon, Korea. sejoong@ajou.ac.kr
- Publication Type:Original Article
- Keywords:
Cyclooxygenase-2;
p53;
prognosis;
renal cell carcinoma
- MeSH:
Carcinoma, Renal Cell/*metabolism/mortality/pathology;
Humans;
Kidney Neoplasms/*metabolism/mortality/pathology;
Prognosis;
Prostaglandin-Endoperoxide Synthase/*metabolism;
Protein p53/*metabolism;
Tumor Markers, Biological/*metabolism
- From:Yonsei Medical Journal
2005;46(1):133-140
- CountryRepublic of Korea
- Language:English
-
Abstract:
The aim of this study was to investigate the relationship of cyclooxygenase (COX) -2 and p53 expression with prognosis in patients with conventional renal cell carcinoma (RCC). Formalin-fixed, paraffin-embedded tissue sections of conventional RCC from 92 patients, who had undergone radical nephrectomy, were examined for COX-2 and p53 expression by immunohistochemistry and compared with clinicopathological variables. The COX-2 expression significantly correlated only with tumor size (p=0.049), whereas the p53 expression profoundly correlated with the TNM stage (p=0.024), M stage (p=0.001), and metastasis (synchronous or metachronous; p= 0.004). The COX-2 overexpression did not significantly associate with p53 positivity (p=0.821). The survival rate of patients correlated with the p53 expression (p < 0.0001) but not with the COX-2 expression (p=0.7506). Multivariate analyses indicated that tumor size, M stage, and p53 expression were independent prognostic factors for cancer-specific survival. The COX-2 expression was not an independent factor. These results show that the increased expression of p53 was associated with metastasis and a worse prognosis in conventional RCC, which suggests that p53 might have played an important role in the progression of conventional RCC. The increased expression of COX-2 was associated only with tumor size, but may not be an important prognostic factor in conventional RCC. No association was observed between COX-2 overexpression and p53 positivity in conventional RCC.
