A preliminary study on the changes of cholinesterase activity, MetHb rate and acid-base balance in rabbits with padan, basa, acephate treatment
- Author:
Nguyen Quang Trung
- Publication Type:Journal Article
- Keywords:
Poisoning
- MeSH:
Cholinesterases;
Acid-Base Equilibrium;
Therapeutics;
Thiocarbamates;
Organothiophosphorus Compounds
- From:Journal of Medical Research
2004;27(1):11-16
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
The effects of insecticides padan, bassa (carbamate) and acephate (OP) on P.ChE activity, MetHb rate and acid-base balance were determined in rabbits. The rabbits were treated by oral administration. Results: In the first group plasma cholinesterase (P.ChE) activity was significantly decreased while methemoglobin (MetHb) rate was significantly increased at 2h and 4h and returned to the before treatment at 24h. The rabbits were mixed alkalosis at 2h, respiratory alkalosis at 4h. In the second group P.ChE activity significantly decreased, MetHb rate significantly increased at 2h and 4h of treatment and then returned to the normal levels at 24h. The rabbits were mixed alkalosis at 2h, respiratory alkalosis at 4h. In the third group P.ChE activity significantly decreased, MetHb rate significantly increased at 3h and 6h and not returned to the before treatment at 24h. The rabbits have respiratory alkalosis at 3h, metabolic acidosis at 6h
