A preliminary investigation of relations of fat mass and leptin to the bone mineral density in ovariectomic rats.
- Author:
Lin QIAO
1
;
Liangzhi XU
;
Dingzhuo YANG
;
Liang LI
;
Li DENG
;
Kehui XU
;
Jing ZHUANG
Author Information
1. Department of Obstetrics and Gynecology, West China Second Hospital of Sichuan University, Chengdu 610041, China.
- Publication Type:Journal Article
- MeSH:
Adipose Tissue;
metabolism;
Animals;
Bone Density;
Female;
Leptin;
blood;
Osteoporosis;
etiology;
Ovariectomy;
Random Allocation;
Rats;
Rats, Wistar
- From:
Journal of Biomedical Engineering
2011;28(4):744-747
- CountryChina
- Language:Chinese
-
Abstract:
The present paper is aimed to investigate the correlation between the fat mass and the bone mass, and to investigate the effect of leptin on bone metabolism in female ovariectomic rats. Forty Wistar female rats, 6-month-old, were randomly divided into the sham surgical (Sham) group and ovariectomic (OVX) group. The body weight, the fat mass inside the abdominal cavity, the bone mineral density (BMD) were determined by DEXA method, and the concentration of leptin was measured by ELISA after operation. The Rats' body mass in ovariectomized group increased significantly (P < 0.05), while the fat mass in abdominal cavity was not increased obviously in ovariectomized group (P = 0.499). The concentration of leptin was no difference between the two groups (P = 0.166). Bone mineral content (BMC)/weight in ovariectomized group was decreased significantly than the sham group (P = 0. 003). The weight at 8th week post-operation was negative correlation with BMC/weight in Sham group and was positive with BMD in OVX group. The fat mass and the leptin concentration were negative correlation with BMC/ weight in Sham group. It was concluded that the fat mass and the leptin were raleted to the BMC/weight.
