Simulation of extracellular action potential for hippocampal pyramidal neurons.
- Author:
Pengju YANG
1
;
Zhouyan FENG
Author Information
1. Key Lab of Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrumentation Science, Zhejiang University, Hangzhou 310027, China.
- Publication Type:Journal Article
- MeSH:
Action Potentials;
physiology;
Animals;
Computer Simulation;
Hippocampus;
cytology;
physiopathology;
Models, Biological;
Neurons;
physiology;
Pyramidal Cells;
physiopathology;
Rats
- From:
Journal of Biomedical Engineering
2011;28(5):1007-1013
- CountryChina
- Language:Chinese
-
Abstract:
In order to extract more information from extracellular action potential (EAP) of neurons recorded deep in the brain tissue, we established simulation models of various pyramidal neurons in the hippocampal CA1 region and investigated the effects of dendrite currents, cell morphology and ion mechanisms on the formation of EAP waveforms. The results show that dendrite currents have significant effects on the EAP at the locations far from cell body, but not on those near cell body. The differences of shape of various pyramidal neurons result in large changes in the EAP amplitudes. However, the shapes of these different EAP are very similar. Ion mechanisms, such as calcium channels, have little effect on EAP waveforms. These results provide important information for experimental EAP recordings, EAP data analysis, and developing new methods to extract more neuronal data from EAP.
