Postoperative Adjuvant Radiation Therapy in Endometrial Carcinoma.
- Author:
Kyung Hwan SHIN
;
Eun Kyung CHOI
;
Seung Do AHN
;
Hyesook CHANG
;
Jung Eun MOK
;
Joo Hyun NAM
;
Young Tak KIM
;
Yong Man KIM
;
Jong Hyeok KIM
- Publication Type:Original Article
- Keywords:
Endometrial cancer;
Radiation therapy;
Vaginal irradiation
- MeSH:
Chungcheongnam-do;
Disease-Free Survival;
Endometrial Neoplasms*;
Female;
Hemorrhage;
Humans;
Hysterectomy;
Lung;
Lymph Node Excision;
Lymph Nodes;
Neoplasm Metastasis;
Radiotherapy, Adjuvant;
Recurrence
- From:The Journal of the Korean Society for Therapeutic Radiology and Oncology
2000;18(1):40-45
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the histopathological prognostic factors, relapse pattern and survival in patients with endometrial carcinoma who were treated with surgery and postoperative adjuvant radiotherapy (RT). METHODS AND MATERIALS: From September 1991 to December 1997, 27 patients with endometrial carcinoma treated with surgery and postoperative adjuvant RT at Asan Medical Center were entered in this study. Surgery was performed with total abdominal hysterectomy in six, total abdominal hysterectomy with pelvic lymph node dissection in eight and radical hysterectomy in 13 patients. External RT of 50.4 Gy was done to all patients and among these, additional high dose rate vaginal vault irradiation of 20-25 Gy with fractional dose of 4-5 Gy was boosted in 16 patients. The patients were followed for 6-95 months (median 30). RESULTS: The number of patients according to FIGO stage were I 18 (67%), II 1 (4%) and III 7 (26%). Patients with poor histologic grade, deep myometrial invasion, adnexal involvement, lymphovascular invasion showed more pelvic lymph node involvement, but no statistical significance was indicated. The 5year overall and disease free survival were 100% and 76.8%, respectively. Relapse sites were pelvic, para-aortic lymph node, and multiple metastases including lung, and no vaginal relapse was developed. Factors that were associated with disease free survival were FIGO stage (p=0.01), lymphovascular invasion (p=0.03), pelvic lymph node involvement (p=0.000 1). There was only one Grade 1 rectal bleeding without moderate to severe complications. CONCLUSION: Postoperative adjuvant RT is considered to reduce the loco-regional failure, resulting the improvement of survival. The group of patients with the risk of vaginal failure without vaginal vault irradiation should be investigated according to stage and grade.
