Clinicopathologic analysis of HIV-negative plasmablastic lymphoma.
- Author:
Yu CHEN
1
;
Yanhui LIU
2
;
Donglan LUO
;
Fen ZHANG
;
Fangping XU
;
Yan GE
;
Xinlan LUO
;
Jie CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Diagnosis, Differential; Female; HIV Seronegativity; Humans; Immunophenotyping; Lymphoma, B-Cell; diagnosis; Male; Middle Aged; Plasma Cells; classification; Plasmablastic Lymphoma; diagnosis; pathology; Prognosis; Translocation, Genetic
- From: Chinese Journal of Pathology 2015;44(8):548-552
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the clinical, pathologic, immunophenotype, molecular characteristics and prognosis of HIV-negative plasmablastic lymphoma (PBL).
METHODSTwelve cases of HIV-negative PBLs diagnosed between 2005 and 2014 in Guangdong General Hospital were identified according to WHO classification of tumors of haematopoietic and lymphoid tissues (2008). The clinicopathologic features and outcome were analyzed and the relevant literatures were reviewed.
RESULTSThe patients were predominantly male (11/12) with a median age of 55.5 years. The tumor cells showed the characteristic combination of immunoblastic/plasmablastic morphology, plasma cell phenotype and high proliferation, no expression of mature B cell markers. 7/10 of the cases were EBER positive. Two cases were positive for C-myc translocation. Four of twelve patients were died.
CONCLUSIONSPBL is a rare, aggressive B-cell lymphoma. HIV-negative PBL has lower rate of oral involvement and EBER expression than HIV-positive patients, the differential diagnosis is very challenging, and the prognosis is worse.
