Effect of iptkalim on myocardial enzymes and free radicals metabolism with hypoxic pulmonary hypertension.
- Author:
Jian-Hua CUI
1
;
Liang GAO
;
Dong-Xiang ZHANG
;
Zhong-Hai XIAO
;
Hai-Jun YANG
;
Bin LI
;
Guang-Quan MA
;
Hai WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Altitude; Creatine Kinase; blood; Free Radicals; metabolism; Humans; Hypertension, Pulmonary; blood; etiology; metabolism; Hypoxia; complications; L-Lactate Dehydrogenase; blood; Male; Myocardium; enzymology; Potassium Channels; agonists; Propylamines; pharmacology; Young Adult
- From: Chinese Journal of Applied Physiology 2012;28(5):385-388
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the effects of iptkalim on myocardial enzymes and free radicals metabolism with hypoxic pulmonary hypertension (HPH), in order to provide evidence for the mechanism of iptkalim on clinical treat.
METHODS110 young men stayed at high altitude above 5 000 m were divided into iptkalim group (n = 74) and placebo group (n = 36), aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyltransferase (gamma-GT), creatine kinase (CK), lactate dehydrogenase (LDH), superoxide dismutase (SOD), malonaldehyde (MDA), nitric oxide(NO) and nitric oxide synthase(NOS) were detected before and after took medicines for 6 mouths.
RESULTSAfter took medication for 6 mouths, ALT, AST, gamma-GT, CK and LDH were reduced, SOD, NO, and NOS were increased, MDA were reduced, there were very significant difference (P < 0.05).
CONCLUSIONOxygen free radicals have taken part in the process of HPH, iptkalim have the effect of anti-peroxidation of lipid and protect myocardial cells stress injured by hypoxia which related with mitochondrial membrane and cell membrane's K(ATP) channel activation.
