Effect of high mobility group box-1 protein on immune cells and its regulatory mechanism.
- Author:
Ying-Yi LUAN
1
;
Feng-Hua YAO
;
Qing-Hong ZHANG
;
Xiao-Mei ZHU
;
Ning DONG
;
Yong-Ming YAO
Author Information
1. Burns Institute, First Hospital Affiliated to the Chinese PLA General Hospital, Beijing 100048, China.
- Publication Type:Journal Article
- MeSH:
Cytokines;
immunology;
HMGB1 Protein;
immunology;
Humans;
Immunity, Cellular;
Inflammation;
immunology
- From:
Chinese Journal of Applied Physiology
2012;28(6):548-554
- CountryChina
- Language:English
-
Abstract:
High mobility group box-1 protein (HMGB1), which is a nuclear protein, participates in chromatin architecture and transcriptional regulation. When released from cells, HMGB1 also plays a well-established role as a pro-inflammatory mediator during innate immune responses to injury. In the initial stage of injury, there is a release of large quantities of early pro-inflammatory mediators to initiate or perpetuate immune responses against pathogens, but this pro-inflammatory period is transient, and it is followed by a prolonged period of immune suppression. At present, several lines of evidences have suggested that HMGB1 is a late cytokine provoking delayed endotoxin morbidity, which may enhance the production of early proinflammatory mediators, and it can contribute potently to the activation of different immune cells and play a role in the development of host cell-mediated immunity. The biology of HMGB1 has been extensively studied as a pro-inflammatory cytokine of systemic inflammation, however, this review will attempt to provide a summary of the effects of HMGB1 on different immune cells and its regulatory mechanism in acute insults.
