The expression and significance of chromogranin A and synaptophysin in adrenal gland tumors.
- Author:
Chao FENG
1
;
Han-zhong LI
;
Wei-gang YAN
;
Yu-feng LUO
;
Jin-ling CAO
Author Information
- Publication Type:Journal Article
- MeSH: Adrenal Gland Neoplasms; diagnosis; metabolism; Adrenocortical Adenoma; diagnosis; metabolism; Adrenocortical Carcinoma; diagnosis; metabolism; Chromogranin A; biosynthesis; genetics; Diagnosis, Differential; Female; Humans; Male; Pheochromocytoma; diagnosis; metabolism; Synaptophysin; biosynthesis; genetics
- From: Chinese Journal of Oncology 2005;27(8):486-488
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of chromogranin A (CgA) and synaptophysin (Syn) for differential diagnosis of different kinds of adrenal gland tumors.
METHODSThe samples of 69 adrenal gland tumors and 4 normal adrenal glands were immunohistochemically analyzed for the expression of chromogranin A and synaptophysin. The statistical analysis of the data was performed using chi-square test.
RESULTSIn the normal adrenal gland, CgA and Syn was exclusively detected in the medulla. CgA was detected in all pheochromocytomas 25/25 (100%), and gave less or no expression in adrenocortical tumors. Syn was detected in adrenocortical adenomas 27/28 (96.4%), adrenocortical carcinoma 7/8 (87.5%), pheochromocytoma 24/25 (96.0%) and adrenal metastatic carcinoma 6/8 (75.0%), respectively.
CONCLUSIONThere is statistically significant difference of CgA expression between adrenalcortical and adrenal medullary tumors, and also between benign and malignant pheochromocytomas. CgA and Syn are immunohistochemically reliable markers in the differential diagnosis of various kinds of adrenal gland tumors.
