The relationship between 99mTc-MIBI scintimammography of breast cancer and multidrug-resistant proteins.
- Author:
Shu-de CUI
1
;
Zhen-zhen LIU
;
Hui LIU
;
Lian-fang LI
;
Hui YANG
;
Wen-liang LI
Author Information
- Publication Type:Journal Article
- MeSH: ATP Binding Cassette Transporter, Sub-Family B; analysis; Adult; Aged; Breast Neoplasms; chemistry; diagnostic imaging; Carcinoma, Ductal, Breast; chemistry; diagnostic imaging; DNA Topoisomerases, Type II; analysis; Drug Resistance, Multiple; Female; Glutathione S-Transferase pi; analysis; Humans; Immunohistochemistry; Middle Aged; Multidrug Resistance-Associated Proteins; analysis; Radionuclide Imaging; Radiopharmaceuticals; Technetium Tc 99m Sestamibi
- From: Chinese Journal of Oncology 2005;27(10):606-608
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the relationship between the clearance rate of technetium-99m methoxyisobutylisonitrile ((99m)Tc-MIBI) in scintimammography and multidrug-resistant proteins expression in breast cancer tissues.
METHODSSeventy-six patients with breast cancer underwent (99m)Tc-MIBI scintimammography before treatment, and static planar images were taken at 10 min and 180 min after scintimammography. The clearance rate of (99m)Tc-MIBI was calculated in each patient. Immunohistochemical analysis was performed on pathological specimens of the 76 breast tumors to determine the expression of P-glycoprotein (P-gp), glutathione S-transferase Pi (GST-pi) and topoisomerase II (Topo II).
RESULTSThe clearance rate was significantly higher in 36 patients with positive P-gp expression when compared with that in 40 patients with negative P-gp expression. There was no significant relationship between GST-pi, Topo II and the clearance rate of (99m)Tc-MIBI.
CONCLUSIONThe clearance rate of (99m)Tc-MIBI in breast imaging may be used to evaluate the P-gp level in breast cancers.
